{"id":16612,"date":"2024-10-01T15:55:33","date_gmt":"2024-10-01T13:55:33","guid":{"rendered":"https:\/\/parkinsonfonds.nl\/?post_type=onderzoek&#038;p=16612"},"modified":"2025-03-31T13:51:11","modified_gmt":"2025-03-31T11:51:11","slug":"validatie-van-microglia-histamine-h4-receptor-antagonisme-voor-de-behandeling-van-de-ziekte-van-parkinson","status":"publish","type":"onderzoek","link":"https:\/\/parkinsonfonds.nl\/en\/onderzoek\/validatie-van-microglia-histamine-h4-receptor-antagonisme-voor-de-behandeling-van-de-ziekte-van-parkinson\/","title":{"rendered":"Validatie van microglia Histamine H4 receptor antagonisme voor de behandeling van de ziekte van Parkinson"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"16612\" class=\"elementor elementor-16612\" data-elementor-post-type=\"onderzoek\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb5ee3b overview-light hero-header e-flex e-con-boxed e-con e-child\" data-id=\"cb5ee3b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-25fc975 hero-section_holder e-flex e-con-boxed e-con e-child\" data-id=\"25fc975\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3a0a5fa e-flex e-con-boxed e-con e-child\" data-id=\"3a0a5fa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b727955 elementor-widget elementor-widget-button\" data-id=\"b727955\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/onderzoek\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-left\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M34.52 239.03L228.87 44.69c9.37-9.37 24.57-9.37 33.94 0l22.67 22.67c9.36 9.36 9.37 24.52.04 33.9L131.49 256l154.02 154.75c9.34 9.38 9.32 24.54-.04 33.9l-22.67 22.67c-9.37 9.37-24.57 9.37-33.94 0L34.52 272.97c-9.37-9.37-9.37-24.57 0-33.94z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Terug naar overzicht<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a290605 e-flex e-con-boxed e-con e-child\" data-id=\"a290605\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f4af2d elementor-widget elementor-widget-heading\" data-id=\"7f4af2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-small\">Validatie van microglia Histamine H4 receptor antagonisme voor de behandeling van de ziekte van Parkinson<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5344dd1 elementor-widget elementor-widget-post-info\" data-id=\"5344dd1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-f7ba8bf elementor-inline-item\" itemprop=\"about\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-terms\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-post-info__terms-list\">\n\t\t\t\t<span class=\"elementor-post-info__terms-list-item\">Genen<\/span>\t\t\t\t<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-6e7f5d8 elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>1 October 2024<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2e06265 e-flex e-con-boxed e-con e-parent\" data-id=\"2e06265\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-347bfb4 e-con-full e-flex e-con e-child\" data-id=\"347bfb4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c758ddb elementor-widget elementor-widget-text-editor\" data-id=\"c758ddb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"none\"><strong>Studie:<\/strong> Validatie van microglia Histamine H4 receptor antagonisme voor de behandeling van de ziekte van Parkinson <\/span><\/p><p><span style=\"text-align: var(--text-align); background-color: var( --e-global-color-2a6d284 ); color: var( --e-global-color-secondary );\" data-contrast=\"none\"><strong>Onderzoeker:<\/strong> dr. Ling Shan (Nederlands Herseninstituut)<\/span><\/p><p><span data-contrast=\"none\"><strong>Looptijd:<\/strong>\u00a04 jaar<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><p><span data-contrast=\"none\"><strong>Subsidie:<\/strong> \u20ac 154.000,-\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-29422db e-con-full e-flex e-con e-child\" data-id=\"29422db\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3ad47fa elementor-widget elementor-widget-image\" data-id=\"3ad47fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/10\/Dr-Ling-Shan-300x300.png\" class=\"attachment-medium size-medium wp-image-34066\" alt=\"Dr.Ling Shan\" srcset=\"https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/10\/Dr-Ling-Shan-300x300.png 300w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/10\/Dr-Ling-Shan-1024x1024.png 1024w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/10\/Dr-Ling-Shan-150x150.png 150w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/10\/Dr-Ling-Shan-768x768.png 768w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/10\/Dr-Ling-Shan.png 1080w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Dr. Ling Shan<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aa5e1bf e-flex e-con-boxed e-con e-parent\" data-id=\"aa5e1bf\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-37e3822 e-con-full e-flex e-con e-child\" data-id=\"37e3822\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-186e910 elementor-widget elementor-widget-heading\" data-id=\"186e910\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Wat zijn de doelen van de studie? <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3e5b53 elementor-widget elementor-widget-text-editor\" data-id=\"b3e5b53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW56740160 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW56740160 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW56740160 BCX0\">Parkinson wordt gekenmerkt door een groot aantal motorische en niet-motorische symptomen met ernstige gevolgen voor het functioneren en de kwaliteit van leven. Het ziekteproces dat leidt tot <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW56740160 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW56740160 BCX0\"> begint al decennia v\u00f3\u00f3r de typische klinische tekenen in de hersenen, wat een optimaal moment is voor vroegtijdige behandeling. Wij vonden veranderingen in de hersenen en in <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW56740160 BCX0\">postmort<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW56740160 BCX0\">um<\/span><span class=\"NormalTextRun SCXW56740160 BCX0\"> weefsel van klinische parkinsonpati\u00ebnten. Wij onderzoeken nu of deze veranderingen ook voorkomen bij donoren met de vroegste stadia van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW56740160 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW56740160 BCX0\">.<\/span> <span class=\"NormalTextRun SCXW56740160 BCX0\">Als we dezelfde toename van histaminereceptoren vinden in het hersenweefsel van vroege parkinsonpati\u00ebnten <\/span><span class=\"NormalTextRun SCXW56740160 BCX0\">kunnen we het <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW56740160 BCX0\">parkinsonproces<\/span> <span class=\"NormalTextRun SCXW56740160 BCX0\">mogelijk <\/span><span class=\"NormalTextRun SCXW56740160 BCX0\">vroeg <\/span><span class=\"NormalTextRun SCXW56740160 BCX0\">remmen.<\/span><span class=\"NormalTextRun SCXW56740160 BCX0\">\u201d\u00a0<\/span><\/span><span class=\"EOP SCXW56740160 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bfb4c62 elementor-widget elementor-widget-heading\" data-id=\"bfb4c62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Hoe pak je het onderzoek aan? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ce6ee0 elementor-widget elementor-widget-text-editor\" data-id=\"0ce6ee0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW225671243 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW225671243 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW225671243 BCX0\">In nauwe samenwerking met de Nederlandse Hersenbank verzamelden we hersenweefsel van donoren zonder <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW225671243 BCX0\">parkinsonsymptomen<\/span><span class=\"NormalTextRun SCXW225671243 BCX0\"> maar met vroege tekenen van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW225671243 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW225671243 BCX0\"> in de hersenen. We analyseren dit weefsel met de nieuwste moleculaire technieken. We onderzoeken nu met een high-<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW225671243 BCX0\">throughput<\/span><span class=\"NormalTextRun SCXW225671243 BCX0\"> moleculaire techniek <\/span><span class=\"NormalTextRun SCXW225671243 BCX0\">\u2013 <\/span><\/span><span class=\"TextRun SCXW225671243 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW225671243 BCX0\">waardoor we veel genen tegelijkertijd via een traject kunnen analyseren<\/span><\/span><span class=\"TextRun SCXW225671243 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW225671243 BCX0\">\u2013<\/span><span class=\"NormalTextRun SCXW225671243 BCX0\"> of deze veranderingen ook voorkomen bij donoren met de vroegste stadia van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW225671243 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW225671243 BCX0\">. Eerder toonden wij in samenwerking met andere groepen in modellen aan dat remming van de histaminereceptor het <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW225671243 BCX0\">parkinsonproces<\/span><span class=\"NormalTextRun SCXW225671243 BCX0\"> remt<\/span><span class=\"NormalTextRun SCXW225671243 BCX0\">.\u201d<\/span><\/span><span class=\"EOP SCXW225671243 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8287a06 elementor-widget elementor-widget-heading\" data-id=\"8287a06\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Wat betekent dit voor de wetenschap en voor pati\u00ebnten? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90fbe93 elementor-widget elementor-widget-text-editor\" data-id=\"90fbe93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW212341478 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW212341478 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW212341478 BCX0\">Als dit resulteert in de aanwezigheid van meer receptoren in een vroeg stadium van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212341478 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW212341478 BCX0\">, is de volgende stap een klinisch onderzoek bij vroege parkinsonpati\u00ebnten met een van de <\/span><span class=\"NormalTextRun SCXW212341478 BCX0\">reeds<\/span><span class=\"NormalTextRun SCXW212341478 BCX0\"> beschikbare remmers van de histaminereceptor. Hiermee zouden we het <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW212341478 BCX0\">parkinsonproces<\/span><span class=\"NormalTextRun SCXW212341478 BCX0\"> dan in een vroegere fase gericht kunnen proberen te remmen<\/span><span class=\"NormalTextRun SCXW212341478 BCX0\">. Ons uiteindelijke doel is het vinden van een vroege behandeling voor pati\u00ebnten.\u201d<\/span><\/span><span class=\"EOP SCXW212341478 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8144ca2 e-con-full e-flex e-con e-child\" data-id=\"8144ca2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f0d1cf8 e-flex e-con-boxed e-con e-parent\" data-id=\"f0d1cf8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-74539a6 e-flex e-con-boxed e-con e-child\" data-id=\"74539a6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7029e1e elementor-widget elementor-widget-heading\" data-id=\"7029e1e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Deel dit artikel<\/h5>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-316c926 e-flex e-con-boxed e-con e-child\" data-id=\"316c926\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-892ad79 elementor-share-buttons--view-icon elementor-share-buttons--skin-flat elementor-share-buttons--color-custom elementor-widget__width-auto elementor-share-buttons--shape-square elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"892ad79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" 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109.807-1.624-7.797-2.599-15.918-2.599-24.04 0-57.828 46.782-104.934 104.934-104.934 30.213 0 57.502 12.67 76.67 33.137 23.715-4.548 46.456-13.32 66.599-25.34-7.798 24.366-24.366 44.833-46.132 57.827 21.117-2.273 41.584-8.122 60.426-16.243-14.292 20.791-32.161 39.308-52.628 54.253z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_facebook\" role=\"button\" tabindex=\"0\" aria-label=\"Share on facebook\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-facebook\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.78 90.69 226.38 209.25 245V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 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54.1 34.8 34.9 56.2 81.2 56.1 130.5 0 101.8-84.9 184.6-186.6 184.6zm101.2-138.2c-5.5-2.8-32.8-16.2-37.9-18-5.1-1.9-8.8-2.8-12.5 2.8-3.7 5.6-14.3 18-17.6 21.8-3.2 3.7-6.5 4.2-12 1.4-32.6-16.3-54-29.1-75.5-66-5.7-9.8 5.7-9.1 16.3-30.3 1.8-3.7.9-6.9-.5-9.7-1.4-2.8-12.5-30.1-17.1-41.2-4.5-10.8-9.1-9.3-12.5-9.5-3.2-.2-6.9-.2-10.6-.2-3.7 0-9.7 1.4-14.8 6.9-5.1 5.6-19.4 19-19.4 46.3 0 27.3 19.9 53.7 22.6 57.4 2.8 3.7 39.1 59.7 94.8 83.8 35.2 15.2 49 16.5 66.6 13.9 10.7-1.6 32.8-13.4 37.4-26.4 4.6-13 4.6-24.1 3.2-26.4-1.3-2.5-5-3.9-10.5-6.6z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f203929 elementor-widget__width-auto custom-share elementor-widget elementor-widget-html\" data-id=\"f203929\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<a class=\"shadow-one\" onclick=\"shareTheLink()\">\n    <span> Anders<\/span>\n<\/a>    \n<script src=\"https:\/\/unpkg.com\/share-api-polyfill\/dist\/share-min.js\"><\/script>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Dr. Ling Shan onderzoekt of het blokkeren van histamine H4-receptoren in microglia kan helpen om het ziekteproces van Parkinson in een vroeg stadium te remmen. Dit onderzoek kan leiden tot nieuwe vroege behandelingen voor de ziekte van Parkinson.<\/p>\n","protected":false},"featured_media":16618,"parent":0,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"soort-onderzoek":[42],"class_list":["post-16612","onderzoek","type-onderzoek","status-publish","has-post-thumbnail","hentry","soort-onderzoek-genen"],"acf":[],"_links":{"self":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/16612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek"}],"about":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/types\/onderzoek"}],"version-history":[{"count":10,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/16612\/revisions"}],"predecessor-version":[{"id":29732,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/16612\/revisions\/29732"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media\/16618"}],"wp:attachment":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media?parent=16612"}],"wp:term":[{"taxonomy":"soort-onderzoek","embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/soort-onderzoek?post=16612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}