{"id":22238,"date":"2025-01-02T09:49:27","date_gmt":"2025-01-02T08:49:27","guid":{"rendered":"https:\/\/parkinsonfonds.nl\/?post_type=onderzoek&#038;p=22238"},"modified":"2025-04-01T14:26:49","modified_gmt":"2025-04-01T12:26:49","slug":"wat-is-de-rol-van-externe-factoren-zoals-covid-op-de-ontwikkeling-van-parkinson","status":"publish","type":"onderzoek","link":"https:\/\/parkinsonfonds.nl\/en\/onderzoek\/wat-is-de-rol-van-externe-factoren-zoals-covid-op-de-ontwikkeling-van-parkinson\/","title":{"rendered":"Wat is de rol van externe factoren, zoals Covid, op de ontwikkeling van parkinson?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22238\" class=\"elementor elementor-22238\" data-elementor-post-type=\"onderzoek\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7fcf6c9 overview-light hero-header e-flex e-con-boxed e-con e-child\" data-id=\"7fcf6c9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7363176 hero-section_holder e-flex e-con-boxed e-con e-child\" data-id=\"7363176\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5a889ea e-flex e-con-boxed e-con e-child\" data-id=\"5a889ea\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7a6259 elementor-widget elementor-widget-button\" data-id=\"e7a6259\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/onderzoek\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-left\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M34.52 239.03L228.87 44.69c9.37-9.37 24.57-9.37 33.94 0l22.67 22.67c9.36 9.36 9.37 24.52.04 33.9L131.49 256l154.02 154.75c9.34 9.38 9.32 24.54-.04 33.9l-22.67 22.67c-9.37 9.37-24.57 9.37-33.94 0L34.52 272.97c-9.37-9.37-9.37-24.57 0-33.94z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Terug naar overzicht<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34579d1 e-flex e-con-boxed e-con e-child\" data-id=\"34579d1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d6897c0 elementor-widget elementor-widget-heading\" data-id=\"d6897c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-small\">Wat is de rol van externe factoren, zoals Covid, op de ontwikkeling van parkinson?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0d0ba8 elementor-widget elementor-widget-post-info\" data-id=\"a0d0ba8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-f7ba8bf elementor-inline-item\" itemprop=\"about\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-terms\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-post-info__terms-list\">\n\t\t\t\t<span class=\"elementor-post-info__terms-list-item\">Omgeving<\/span>\t\t\t\t<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-6e7f5d8 elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>2 January 2025<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2474d8e e-flex e-con-boxed e-con e-parent\" data-id=\"2474d8e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fabe341 e-con-full e-flex e-con e-child\" data-id=\"fabe341\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6122877 elementor-widget elementor-widget-text-editor\" data-id=\"6122877\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"none\"><strong>Studie:<\/strong> <span class=\"NormalTextRun SCXW106201429 BCX0\">&lt;offici\u00eble titel&gt; <\/span><span class=\"NormalTextRun SCXW106201429 BCX0\">Van virus tot <\/span><span class=\"NormalTextRun SCXW106201429 BCX0\">alfa<\/span><span class=\"NormalTextRun SCXW106201429 BCX0\">&#8211;<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW106201429 BCX0\">synucle\u00efne<\/span><span class=\"NormalTextRun SCXW106201429 BCX0\"> pathologie: <\/span><span class=\"NormalTextRun SCXW106201429 BCX0\">h<\/span><span class=\"NormalTextRun SCXW106201429 BCX0\">oe externe factoren mogelijk bijdragen aan de ontwikkeling van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW106201429 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW106201429 BCX0\">arkinson<\/span><\/span><\/p><p><span style=\"text-align: var(--text-align); background-color: var( --e-global-color-2a6d284 ); color: var( --e-global-color-secondary );\" data-contrast=\"none\"><strong>Onderzoeker:<\/strong> <span class=\"TextRun SCXW199059321 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW199059321 BCX0\">prof. dr. Mireille Claessens, hoogleraar Nanobiofysica, Universiteit Twente<\/span><\/span><span class=\"EOP SCXW199059321 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/span><\/p><p><span data-contrast=\"none\"><strong>Looptijd:<\/strong> 4 jaar<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><p><span data-contrast=\"none\"><strong>Subsidie:<\/strong> <span lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\">\u20ac <\/span><\/span>293.737,-<\/p><p><span class=\"TextRun MacChromeBold SCXW201796864 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW201796864 BCX0\">Welke moleculaire processen zitten er achter factoren die de kans op <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW201796864 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW201796864 BCX0\"> kunnen vergroten? Dat wil prof. dr. Mireille Claessens achterhalen met fundamenteel onderzoek.<\/span><\/span><span class=\"EOP SCXW201796864 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c7558ab e-con-full e-flex e-con e-child\" data-id=\"c7558ab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8695ac4 elementor-widget elementor-widget-image\" data-id=\"8695ac4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/12\/Mireille-Claessens-300x300.png\" class=\"attachment-medium size-medium wp-image-20295\" alt=\"\" srcset=\"https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/12\/Mireille-Claessens-300x300.png 300w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/12\/Mireille-Claessens-1024x1024.png 1024w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/12\/Mireille-Claessens-150x150.png 150w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/12\/Mireille-Claessens-768x768.png 768w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/12\/Mireille-Claessens.png 1080w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Prof. dr. Mireille Claessens<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3c7dd2b e-flex e-con-boxed e-con e-parent\" data-id=\"3c7dd2b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3ac5e5c e-con-full e-flex e-con e-child\" data-id=\"3ac5e5c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ecfd6d elementor-widget elementor-widget-heading\" data-id=\"6ecfd6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Wat is de achtergrond van jullie onderzoek? <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a496a3e elementor-widget elementor-widget-text-editor\" data-id=\"a496a3e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW76360633 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW76360633 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW76360633 BCX0\">De meeste gevallen van de ziekte van Parkinson ontstaan niet door erfelijke\u202ffactoren. Dit suggereert dat andere invloeden een rol spelen bij het ontwikkelen van deze aandoening. Onderzoek wijst erop dat externe factoren zoals virusinfecties en blootstelling aan fijnstof of pesticiden het risico op <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW76360633 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW76360633 BCX0\">arkinson<\/span><span class=\"NormalTextRun SCXW76360633 BCX0\"> kunnen verhogen. Maar waarom deze factoren het risico vergroten, is nog niet duidelijk<\/span><span class=\"NormalTextRun SCXW76360633 BCX0\">. D<\/span><span class=\"NormalTextRun SCXW76360633 BCX0\">e onderliggende moleculaire processen zijn onbekend.<\/span><span class=\"NormalTextRun SCXW76360633 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW76360633 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6a79914 elementor-widget elementor-widget-heading\" data-id=\"6a79914\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Wat zijn de belangrijkste doelen? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79522f6 elementor-widget elementor-widget-text-editor\" data-id=\"79522f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW244524676 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW244524676 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">Ons project richt zich op begrijpen hoe een risicofactor kan leiden tot het samenklonteren van het eiwit <\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">alfa<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">&#8211;<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW244524676 BCX0\">synucle\u00efne<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\"> in zenuwcellen, wat een kenmerk is van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW244524676 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW244524676 BCX0\">arkinson<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">. Recent <\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">ontdekten we<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\"> dat sommige viruseiwitten <\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">\u2013 <\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">o<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">nder andere<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\"> het <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW244524676 BCX0\">nucleocapside<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">&#8211;<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">eiwit van het coronavirus (SARS-CoV-2) <\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">\u2013 <\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">de vorming van deze eiwitklonten in laboratoriumstudies kunnen induceren. We denken dat op deze manier \u00e9\u00e9n enkele gebeurtenis, zoals een virusinfectie, direct kan <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW244524676 BCX0\">triggeren<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\"> dat <\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">alfa-<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW244524676 BCX0\">synucle\u00efne<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\"> gaat samenklonteren.<\/span><span class=\"NormalTextRun SCXW244524676 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW244524676 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a95a0b elementor-widget elementor-widget-heading\" data-id=\"4a95a0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Hoe pakken jullie de studie aan? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-592fc4d elementor-widget elementor-widget-text-editor\" data-id=\"592fc4d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW7831206 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW7831206 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">We willen deze theorie testen door het <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW7831206 BCX0\">nucleocapside<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">-eiwit van SARS-CoV-2 als eerste modelsysteem te gebruiken. Met geavanceerde microscopie- en spectroscopietechnieken <\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">gaan<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\"> we onderzoeken hoe het <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW7831206 BCX0\">nucleocapside<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">&#8211;<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">eiwit de samenklontering van <\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">alfa-<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW7831206 BCX0\">synucle\u00efne<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\"> in cellen veroorzaakt<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">. E<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">n hoe dit leidt tot een kettingreactie die de eiwitklonten naar naburige cellen verspreidt. We verwachten dat onze bevindingen ook toepasbaar zijn op sommige andere risicofactoren<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">, <\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">bijvoorbeeld fijnstof. We hopen dat deze <\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">\u2018<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">single event<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">\u2019<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">-hypothese een nieuw perspectief biedt op het ontstaan van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW7831206 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW7831206 BCX0\">arkinson<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\"> en op mogelijke manieren om dit proces te stoppen.<\/span><span class=\"NormalTextRun SCXW7831206 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW7831206 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5827ba elementor-widget elementor-widget-heading\" data-id=\"c5827ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Kun je nog iets meer vertellen over die microscopietechnieken? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12e97d1 elementor-widget elementor-widget-text-editor\" data-id=\"12e97d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">\u201cWe gaan met behulp van geavanceerde technieken achterhalen hoe eiwitten in zenuwcellen beginnen samen te klonteren. Met ultrasensitieve microscopie kunnen we de allereerste stappen van deze eiwitophoping volgen. We bestuderen ook hoe de pathologie zich van cel tot cel verspreidt, met behulp van de nieuwste labeltechnieken, fluorescentiemicroscopie en andere methoden.<\/span><span data-contrast=\"auto\">\u200b\u200b\u200b\u200b\u200b\u200b\u200b\u201d<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b96c58d elementor-widget elementor-widget-heading\" data-id=\"b96c58d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Waarom is dit onderzoek zo waardevol?  <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-535cc9f elementor-widget elementor-widget-text-editor\" data-id=\"535cc9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW390004 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW390004 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW390004 BCX0\">Met ons onderzoek willen we de kloof dichten tussen wat we weten over risicofactoren voor de ziekte van Parkinson en de onderliggende moleculaire processen. Door beter te begrijpen hoe de ziekte begint, zetten we de eerste stap naar het vertragen van het ziekteproces en het ontwikkelen van preventieve maatregelen.<\/span><span class=\"NormalTextRun SCXW390004 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW390004 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">We werken samen met de neuroloog in het ziekenhuis en spreken regelmatig mensen met parkinson. Zo toetsen we of onze studie inderdaad aan de kern raakt om de oorzaak te achterhalen.\u201d<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46b6f95 elementor-widget elementor-widget-heading\" data-id=\"46b6f95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Wat betekent jullie onderzoek op de lange termijn voor pati\u00ebnten en de wetenschap? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62e3c67 elementor-widget elementor-widget-text-editor\" data-id=\"62e3c67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW234361957 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW234361957 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW234361957 BCX0\">In de afgelopen jaren is duidelijk geworden dat de ziekte van Parkinson niet \u00e9\u00e9n enkele<\/span><span class=\"NormalTextRun SCXW234361957 BCX0\"> oorzaak heeft; veel verschillende factoren kunnen leiden tot het ontstaan ervan. Dit maakt het moeilijk te achterhalen hoe de ziekte zich precies op moleculair niveau ontwikkelt. In ons onderzoek zetten we de eerste stappen om dit beter te begrijpen door gebruik te maken van een relevant modelsysteem. Door te ontdekken hoe <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW234361957 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW234361957 BCX0\">arkinson<\/span><span class=\"NormalTextRun SCXW234361957 BCX0\"> op moleculair niveau kan beginnen, hopen we op de lange termijn een basis te leggen voor preventie of nieuwe behandelingen.<\/span><span class=\"NormalTextRun SCXW234361957 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW234361957 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9198e8 elementor-widget elementor-widget-heading\" data-id=\"d9198e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Wat is je persoonlijke motivatie voor parkinsononderzoek? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc64435 elementor-widget elementor-widget-text-editor\" data-id=\"bc64435\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW176976799 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW176976799 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW176976799 BCX0\">Het is\u202fduidelijk dat de ziekte van Parkinson een zeer complexe aandoening is. Ondanks vele jaren van onderzoek begrijpen we nog steeds niet precies hoe de ziekte ontstaat en wat de onderliggende oorzaken zijn. Ik vind het fascinerend om bij te dragen aan het oplossen van enkele stukjes van deze complexe puzzel. Op deze manier hoop ik <\/span><span class=\"NormalTextRun SCXW176976799 BCX0\">te helpen met<\/span><span class=\"NormalTextRun SCXW176976799 BCX0\"> het vinden van nieuwe manieren om <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW176976799 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW176976799 BCX0\">arkinson<\/span><span class=\"NormalTextRun SCXW176976799 BCX0\"> te voorkomen of te behandelen.<\/span><span class=\"NormalTextRun SCXW176976799 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW176976799 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c7ade2a e-con-full e-flex e-con e-child\" data-id=\"c7ade2a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3b88366 e-flex e-con-boxed e-con e-parent\" data-id=\"3b88366\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-bc9c369 e-flex e-con-boxed e-con e-child\" data-id=\"bc9c369\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-20f03b4 elementor-widget elementor-widget-heading\" data-id=\"20f03b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Deel dit artikel<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-031d553 e-flex e-con-boxed e-con e-child\" data-id=\"031d553\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3c6c9a3 elementor-share-buttons--view-icon elementor-share-buttons--skin-flat elementor-share-buttons--color-custom elementor-widget__width-auto elementor-share-buttons--shape-square elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"3c6c9a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_twitter\" role=\"button\" tabindex=\"0\" aria-label=\"Delen op twitter\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-twitter\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path 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13.9 10.7-1.6 32.8-13.4 37.4-26.4 4.6-13 4.6-24.1 3.2-26.4-1.3-2.5-5-3.9-10.5-6.6z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b22a1d1 elementor-widget__width-auto custom-share elementor-widget elementor-widget-html\" data-id=\"b22a1d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a class=\"shadow-one\" onclick=\"shareTheLink()\">\n    <span> Anders<\/span>\n<\/a>    \n<script src=\"https:\/\/unpkg.com\/share-api-polyfill\/dist\/share-min.js\"><\/script>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Welke moleculaire processen zitten er achter factoren die de kans op parkinson kunnen vergroten? Dat wil prof. dr. Mireille Claessens achterhalen met fundamenteel onderzoek. <\/p>\n","protected":false},"featured_media":22239,"parent":0,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"soort-onderzoek":[45],"class_list":["post-22238","onderzoek","type-onderzoek","status-publish","has-post-thumbnail","hentry","soort-onderzoek-omgeving"],"acf":[],"_links":{"self":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/22238","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek"}],"about":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/types\/onderzoek"}],"version-history":[{"count":10,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/22238\/revisions"}],"predecessor-version":[{"id":30179,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/22238\/revisions\/30179"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media\/22239"}],"wp:attachment":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media?parent=22238"}],"wp:term":[{"taxonomy":"soort-onderzoek","embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/soort-onderzoek?post=22238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}