{"id":26949,"date":"2024-06-03T14:15:56","date_gmt":"2024-06-03T12:15:56","guid":{"rendered":"https:\/\/parkinsonfonds.nl\/?post_type=onderzoek&#038;p=26949"},"modified":"2025-03-31T13:44:23","modified_gmt":"2025-03-31T11:44:23","slug":"de-rol-van-mirnas-in-het-ontstaan-van-parkinson","status":"publish","type":"onderzoek","link":"https:\/\/parkinsonfonds.nl\/en\/onderzoek\/de-rol-van-mirnas-in-het-ontstaan-van-parkinson\/","title":{"rendered":"De rol van miRNA\u2019s in het ontstaan van Parkinson"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"26949\" class=\"elementor elementor-26949\" data-elementor-post-type=\"onderzoek\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb5ee3b overview-light hero-header e-flex e-con-boxed e-con e-child\" data-id=\"cb5ee3b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-25fc975 hero-section_holder e-flex e-con-boxed e-con e-child\" data-id=\"25fc975\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3a0a5fa e-flex e-con-boxed e-con e-child\" data-id=\"3a0a5fa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b727955 elementor-widget elementor-widget-button\" data-id=\"b727955\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/onderzoek\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-left\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M34.52 239.03L228.87 44.69c9.37-9.37 24.57-9.37 33.94 0l22.67 22.67c9.36 9.36 9.37 24.52.04 33.9L131.49 256l154.02 154.75c9.34 9.38 9.32 24.54-.04 33.9l-22.67 22.67c-9.37 9.37-24.57 9.37-33.94 0L34.52 272.97c-9.37-9.37-9.37-24.57 0-33.94z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Terug naar overzicht<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a290605 e-flex e-con-boxed e-con e-child\" data-id=\"a290605\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f4af2d elementor-widget elementor-widget-heading\" data-id=\"7f4af2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-small\">De rol van miRNA\u2019s in het ontstaan van Parkinson<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5344dd1 elementor-widget elementor-widget-post-info\" data-id=\"5344dd1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-f7ba8bf elementor-inline-item\" itemprop=\"about\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-terms\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-post-info__terms-list\">\n\t\t\t\t<span class=\"elementor-post-info__terms-list-item\">Genen<\/span>\t\t\t\t<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-6e7f5d8 elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>3 June 2024<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fbb410c e-flex e-con-boxed e-con e-parent\" data-id=\"fbb410c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-bb15954 e-con-full e-flex e-con e-child\" data-id=\"bb15954\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a0e7404 elementor-widget elementor-widget-text-editor\" data-id=\"a0e7404\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><b>Onderzoek: <\/b><span class=\"TextRun SCXW18266015 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW18266015 BCX0\">Exosome<\/span><span class=\"NormalTextRun SCXW18266015 BCX0\">-afgeleide <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW18266015 BCX0\">microRNA\u2019s<\/span><span class=\"NormalTextRun SCXW18266015 BCX0\"> als potenti\u00eble diagnostische markers en hun rol in de pathofysiologie van de ziekte van Parkinson\u202f<\/span><\/span><\/p><p><b><span data-contrast=\"auto\">Hoofdonderzoeker:\u00a0<\/span><\/b><span data-contrast=\"auto\">dr. James D. Mills &amp; <span class=\"NormalTextRun SCXW249875840 BCX0\">dr. Lucia <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SpellingErrorHighlight SCXW249875840 BCX0\">Mesarosova<\/span><\/span><\/p><p><b><span data-contrast=\"auto\">Affiliatie:<\/span><\/b><span data-contrast=\"auto\"> Amsterdam UMC<\/span><\/p><p><strong>Looptijd:<\/strong> 4 jaar<\/p><p><strong>Subsidie:<\/strong> \u20ac 337.228,-<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-462636e e-con-full e-flex e-con e-child\" data-id=\"462636e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c3c14c2 elementor-widget elementor-widget-image\" data-id=\"c3c14c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/06\/James-D.-Mills-300x300.png\" class=\"attachment-medium size-medium wp-image-26953\" alt=\"\" srcset=\"https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/06\/James-D.-Mills-300x300.png.webp 300w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/06\/James-D.-Mills-1024x1024.png.webp 1024w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/06\/James-D.-Mills-150x150.png.webp 150w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/06\/James-D.-Mills-768x768.png.webp 768w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/06\/James-D.-Mills-400x400.png.webp 400w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/06\/James-D.-Mills-600x600.png.webp 600w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2024\/06\/James-D.-Mills.png.webp 1080w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><br>  Dr. James D. Mills<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-619705b e-flex e-con-boxed e-con e-parent\" data-id=\"619705b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7ee540c e-con-full e-flex e-con e-child\" data-id=\"7ee540c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-018f083 elementor-widget elementor-widget-heading\" data-id=\"018f083\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Doelstellingen\u202f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cefc636 elementor-widget elementor-widget-text-editor\" data-id=\"cefc636\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW123396485 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123396485 BCX0\">Het onderzoek wil begrijpen hoe we kleine deeltjes genaamd <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW123396485 BCX0\">exosomen<\/span><span class=\"NormalTextRun SCXW123396485 BCX0\">, die cellen afgeven, kunnen gebruiken om de ziekte van Parkinson vroegtijdig te diagnosticeren door<\/span><\/span>\u00a0<span class=\"TextRun SCXW123396485 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123396485 BCX0\">hun<\/span><span class=\"NormalTextRun SCXW123396485 BCX0\"> inhoud \u2013 <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW123396485 BCX0\">microRNA\u2019s<\/span><span class=\"NormalTextRun SCXW123396485 BCX0\"> (<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW123396485 BCX0\">miRNA\u2019s<\/span><span class=\"NormalTextRun SCXW123396485 BCX0\">). <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW123396485 BCX0\">MiRNA\u2019s<\/span><span class=\"NormalTextRun SCXW123396485 BCX0\"> zijn kleine moleculen die de activiteit van genen kunnen regelen. Dit onderzoek wil:<\/span><\/span><span class=\"TextRun SCXW123396485 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123396485 BCX0\">\u202f<\/span><\/span><span class=\"TextRun SCXW123396485 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123396485 BCX0\">\u202f<\/span><\/span><span class=\"EOP SCXW123396485 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p><ul><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Specifieke miRNA\u2019s in lichaamsvloeistoffen identificeren die verband houden met de ziekte van Parkinson.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li><\/ul><ul><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"2\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Deze bevindingen bevestigen in een grotere groep mensen om de resultaten te versterken.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"3\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Celmodellen gebruiken om te onderzoeken hoe deze miRNA\u2019s de ontwikkeling van de ziekte be\u00efnvloeden.<br \/><\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li><\/ul><p><span data-contrast=\"auto\">Dit kan baanbrekend zijn aangezien het vinden van deze markers kan helpen bij het vroeg diagnosticeren van parkinson, ver voordat ernstige symptomen verschijnen. Momenteel bestaan er namelijk geen definitieve diagnostische tests voor de vroege stadia.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6882a34 elementor-widget elementor-widget-heading\" data-id=\"6882a34\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Onderzoeksdetails\u202f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f9c6feb elementor-widget elementor-widget-text-editor\" data-id=\"f9c6feb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW257900275 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW257900275 BCX0\">De onderzoekers passen geavanceerde genetische technieken toe om <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW257900275 BCX0\">miRNA\u2019s<\/span> <\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW257900275 BCX0\"><span class=\"TextRun SCXW257900275 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW257900275 BCX0\">te identificeren <\/span><\/span><\/span><span data-contrast=\"auto\">en te valideren uit exosomen in het ruggenmergvocht en bloedplasma. Ze zullen:<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><ul><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Een methode genaamd kleine RNA-sequencing gebruiken om miRNA\u2019s in de initi\u00eble tests te vinden.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li><\/ul><ul><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Deze miRNA\u2019s bevestigen met een grotere steekproef met een methode genaamd TaqMan-PCR.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li><\/ul><ul><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Deze miRNA\u2019s bestuderen in celmodellen om hun rol in parkinson te begrijpen.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<br \/><br \/><\/span><\/li><\/ul><p><span data-contrast=\"auto\">Ze verwachten miRNA\u2019s te identificeren die in concentratie veranderen in relatie tot de ontwikkeling van parkinson. <span class=\"TextRun SCXW222997633 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW222997633 BCX0\">Deze kunnen <\/span><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW222997633 BCX0\">mogelijk <\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW222997633 BCX0\"><span class=\"TextRun SCXW222997633 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW222997633 BCX0\">worden<\/span><\/span><\/span> <span class=\"TextRun SCXW222997633 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW222997633 BCX0\">gebruikt <span class=\"TextRun SCXW121853400 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW121853400 BCX0\">als biologische markers voor vroege diagnose en monitoring van de ziekte.<\/span><\/span><span class=\"TextRun SCXW121853400 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW121853400 BCX0\">\u202f<\/span><\/span><span class=\"TextRun SCXW121853400 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW121853400 BCX0\">\u202f<\/span><\/span><\/span><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a64e61e elementor-widget elementor-widget-heading\" data-id=\"a64e61e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Gewenste uitkomst\u202f <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0398f9b elementor-widget elementor-widget-text-editor\" data-id=\"0398f9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">De gewenste resultaten van dit onderzoek zijn:<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><ul><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Een lijst vaststellen van miRNA-moleculen die consistent veranderd zijn bij parkinsonpati\u00ebnten in vergelijking met gezonde controles.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li><\/ul><ul><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Deze miRNA\u2019s valideren in een grotere populatie om te zorgen dat ze betrouwbare markers zijn.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li><\/ul><ul><li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Laboratoriummodellen ontwikkelen om te verkennen hoe we deze miRNA\u2019s kunnen gebruiken om in te grijpen in het ziekteproces, wat mogelijk leidt tot nieuwe behandelingen.<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-44be275 elementor-widget elementor-widget-heading\" data-id=\"44be275\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Context voor pati\u00ebnten, onderzoekers, verzorgers en mensen die dit onderzoek financieren\u202f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f92666 elementor-widget elementor-widget-text-editor\" data-id=\"5f92666\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW217575838 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW217575838 BCX0\">Voor pati\u00ebnten en verzorgers biedt dit onderzoek hoop op vroege diagnose en mogelijk effectievere behandelingen die de voortgang van de ziekte van Parkinson kunnen vertragen of veranderen. Voor onderzoekers opent deze studie nieuwe wegen om de moleculaire mechanismen van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW217575838 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW217575838 BCX0\"> te verkennen en therapie\u00ebn te ontwikkelen die deze specifieke <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW217575838 BCX0\">miRNA\u2019s<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SpellingErrorHighlight SCXW217575838 BCX0\">targeten<\/span><span class=\"NormalTextRun SCXW217575838 BCX0\">.\u202f\u202f<\/span><\/span><span class=\"EOP SCXW217575838 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p><p><span class=\"NormalTextRun SCXW141357713 BCX0\">Financiers en medische instellingen zijn mogelijk ge\u00efnteresseerd in deze <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW141357713 BCX0\">biomarkers<\/span><span class=\"NormalTextRun SCXW141357713 BCX0\"> om significante vooruitgang<\/span><span class=\"TextRun SCXW172583380 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW172583380 BCX0\">in<\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW172583380 BCX0\"><span class=\"TextRun SCXW172583380 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW172583380 BCX0\"> het<\/span><\/span><\/span><span class=\"TextRun SCXW172583380 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW172583380 BCX0\"> beheer en <\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW172583380 BCX0\"><span class=\"TextRun SCXW172583380 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW172583380 BCX0\">de <\/span><\/span><\/span><span class=\"TextRun SCXW172583380 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW172583380 BCX0\">behandeling van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW172583380 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW172583380 BCX0\">. Eerder ingrijpen in het verloop van de ziekte <\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW172583380 BCX0\"><span class=\"TextRun SCXW172583380 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW172583380 BCX0\">kan mogelijk de lange termijn zorgkosten verminderen.<\/span><\/span><\/span><\/p><p><span class=\"TextRun SCXW120134169 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW120134169 BCX0\">Dit onderzoek is cruciaal omdat het een van de hoofduitdagingen in de behandeling van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW120134169 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW120134169 BCX0\"> aanpakt: het gebrek aan vroege diagnostische methoden. <\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW120134169 BCX0\"><span class=\"TextRun SCXW120134169 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW120134169 BCX0\">Als we Parkinson kunnen <\/span><\/span><\/span><span data-contrast=\"auto\">diagnosticeren via een simpele bloedtest, voordat ernstige symptomen zelfs maar verschijnen, kan dit de levenskwaliteit van mensen met parkinson aanzienlijk verbeteren. Bijvoorbeeld door het uitstellen van de aanvang van ernstige motorische symptomen en door vroegere, effectievere managementopties mogelijk te maken. Dit kan ook betere klinische proeven voor nieuwe behandelingen faciliteren, aangezien individuen eerder in het ziekteproces kunnen worden ge\u00efdentificeerd.<\/span><span data-contrast=\"auto\">\u202f<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-473bd3a e-con-full e-flex e-con e-child\" data-id=\"473bd3a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f0d1cf8 e-flex e-con-boxed e-con e-parent\" data-id=\"f0d1cf8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-74539a6 e-flex e-con-boxed e-con e-child\" data-id=\"74539a6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7029e1e elementor-widget elementor-widget-heading\" data-id=\"7029e1e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Deel dit artikel<\/h5>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-316c926 e-flex e-con-boxed e-con e-child\" data-id=\"316c926\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-892ad79 elementor-share-buttons--view-icon elementor-share-buttons--skin-flat elementor-share-buttons--color-custom elementor-widget__width-auto elementor-share-buttons--shape-square elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"892ad79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_twitter\" role=\"button\" tabindex=\"0\" aria-label=\"Delen op twitter\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-twitter\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M459.37 151.716c.325 4.548.325 9.097.325 13.645 0 138.72-105.583 298.558-298.558 298.558-59.452 0-114.68-17.219-161.137-47.106 8.447.974 16.568 1.299 25.34 1.299 49.055 0 94.213-16.568 130.274-44.832-46.132-.975-84.792-31.188-98.112-72.772 6.498.974 12.995 1.624 19.818 1.624 9.421 0 18.843-1.3 27.614-3.573-48.081-9.747-84.143-51.98-84.143-102.985v-1.299c13.969 7.797 30.214 12.67 47.431 13.319-28.264-18.843-46.781-51.005-46.781-87.391 0-19.492 5.197-37.36 14.294-52.954 51.655 63.675 129.3 105.258 216.365 109.807-1.624-7.797-2.599-15.918-2.599-24.04 0-57.828 46.782-104.934 104.934-104.934 30.213 0 57.502 12.67 76.67 33.137 23.715-4.548 46.456-13.32 66.599-25.34-7.798 24.366-24.366 44.833-46.132 57.827 21.117-2.273 41.584-8.122 60.426-16.243-14.292 20.791-32.161 39.308-52.628 54.253z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_facebook\" role=\"button\" tabindex=\"0\" aria-label=\"Delen op facebook\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-facebook\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.78 90.69 226.38 209.25 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38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_whatsapp\" role=\"button\" tabindex=\"0\" aria-label=\"Delen op whatsapp\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-whatsapp\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M380.9 97.1C339 55.1 283.2 32 223.9 32c-122.4 0-222 99.6-222 222 0 39.1 10.2 77.3 29.6 111L0 480l117.7-30.9c32.4 17.7 68.9 27 106.1 27h.1c122.3 0 224.1-99.6 224.1-222 0-59.3-25.2-115-67.1-157zm-157 341.6c-33.2 0-65.7-8.9-94-25.7l-6.7-4-69.8 18.3L72 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data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<a class=\"shadow-one\" onclick=\"shareTheLink()\">\n    <span> Anders<\/span>\n<\/a>    \n<script src=\"https:\/\/unpkg.com\/share-api-polyfill\/dist\/share-min.js\"><\/script>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Het onderzoek wil begrijpen hoe we kleine deeltjes genaamd exosomen, die cellen afgeven, kunnen gebruiken om de ziekte van Parkinson vroegtijdig te diagnosticeren door hun inhoud \u2013 microRNA\u2019s (miRNA\u2019s). MiRNA\u2019s zijn kleine moleculen die de activiteit van genen kunnen regelen.<\/p>\n","protected":false},"featured_media":26950,"parent":0,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"soort-onderzoek":[42],"class_list":["post-26949","onderzoek","type-onderzoek","status-publish","has-post-thumbnail","hentry","soort-onderzoek-genen"],"acf":[],"_links":{"self":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/26949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek"}],"about":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/types\/onderzoek"}],"version-history":[{"count":6,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/26949\/revisions"}],"predecessor-version":[{"id":29722,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/26949\/revisions\/29722"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media\/26950"}],"wp:attachment":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media?parent=26949"}],"wp:term":[{"taxonomy":"soort-onderzoek","embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/soort-onderzoek?post=26949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}