{"id":38221,"date":"2026-06-11T09:53:43","date_gmt":"2026-06-11T07:53:43","guid":{"rendered":"https:\/\/parkinsonfonds.nl\/?post_type=onderzoek&#038;p=38221"},"modified":"2026-06-11T16:20:45","modified_gmt":"2026-06-11T14:20:45","slug":"karakterisering-en-behandeling-van-de-pp2a-lrrk2-route-bij-de-ziekte-van-parkinson","status":"publish","type":"onderzoek","link":"https:\/\/parkinsonfonds.nl\/en\/onderzoek\/karakterisering-en-behandeling-van-de-pp2a-lrrk2-route-bij-de-ziekte-van-parkinson\/","title":{"rendered":"Karakterisering en behandeling van de PP2A\/LRRK2-route bij de ziekte van Parkinson"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"38221\" class=\"elementor elementor-38221\" data-elementor-post-type=\"onderzoek\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb5ee3b overview-light hero-header e-flex e-con-boxed e-con e-child\" data-id=\"cb5ee3b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-25fc975 hero-section_holder e-flex e-con-boxed e-con e-child\" data-id=\"25fc975\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3a0a5fa e-flex e-con-boxed e-con e-child\" data-id=\"3a0a5fa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b727955 elementor-widget elementor-widget-button\" data-id=\"b727955\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/onderzoek\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-left\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M34.52 239.03L228.87 44.69c9.37-9.37 24.57-9.37 33.94 0l22.67 22.67c9.36 9.36 9.37 24.52.04 33.9L131.49 256l154.02 154.75c9.34 9.38 9.32 24.54-.04 33.9l-22.67 22.67c-9.37 9.37-24.57 9.37-33.94 0L34.52 272.97c-9.37-9.37-9.37-24.57 0-33.94z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Terug naar overzicht<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a290605 e-flex e-con-boxed e-con e-child\" data-id=\"a290605\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f4af2d elementor-widget elementor-widget-heading\" data-id=\"7f4af2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-small\">Karakterisering en behandeling van de PP2A\/LRRK2-route bij de ziekte van Parkinson<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5344dd1 elementor-widget elementor-widget-post-info\" data-id=\"5344dd1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-f7ba8bf elementor-inline-item\" itemprop=\"about\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-terms\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-post-info__terms-list\">\n\t\t\t\t<span class=\"elementor-post-info__terms-list-item\">Genen<\/span>\t\t\t\t<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-6e7f5d8 elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>11 June 2026<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fbb410c e-flex e-con-boxed e-con e-parent\" data-id=\"fbb410c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-bb15954 e-con-full e-flex e-con e-child\" data-id=\"bb15954\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-648bebd elementor-widget elementor-widget-text-editor\" data-id=\"648bebd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>Hoofdonderzoeker:<\/strong> p<span class=\"TextRun SCXW31904622 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun CommentHighlightClicked SCXW31904622 BCX0\" data-ccp-parastyle=\"heading 4\">rof.\u00a0<\/span><span class=\"NormalTextRun CommentHighlightClicked SCXW31904622 BCX0\" data-ccp-parastyle=\"heading 4\">d<\/span><span class=\"NormalTextRun CommentHighlightClicked SCXW31904622 BCX0\" data-ccp-parastyle=\"heading 4\">r. A.\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed CommentHighlightClicked SCXW31904622 BCX0\" data-ccp-parastyle=\"heading 4\">Kortholt<\/span><span class=\"NormalTextRun CommentHighlightClicked SCXW31904622 BCX0\" data-ccp-parastyle=\"heading 4\">, Rijksuniversiteit Groningen<\/span><\/span><span class=\"EOP CommentHighlightClicked SCXW31904622 BCX0\" data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;201341983&quot;:0,&quot;335559738&quot;:319,&quot;335559739&quot;:319,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><li><strong>In samenwerking met:<\/strong><span class=\"TextRun SCXW132161489 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun CommentHighlightClicked SCXW132161489 BCX0\" data-ccp-parastyle=\"heading 4\">d<\/span><span class=\"NormalTextRun CommentHighlightClicked SCXW132161489 BCX0\" data-ccp-parastyle=\"heading 4\">r.\u00a0<\/span><\/span><span class=\"TextRun SCXW132161489 BCX0\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun CommentHighlightClicked SCXW132161489 BCX0\" data-ccp-parastyle=\"heading 4\">Hardy Rideout, Biomedical Research Foundation, Academie van Athene <\/span><span class=\"NormalTextRun SpellingErrorV2Themed CommentHighlightRest SCXW132161489 BCX0\" data-ccp-parastyle=\"heading 4\">en <\/span><span class=\"NormalTextRun CommentHighlightRest SCXW132161489 BCX0\" data-ccp-parastyle=\"heading 4\">post-doc Panagiotis Athanasopoulos<\/span><\/span><\/li><li><strong>Projectduur:<\/strong> 2 jaar<\/li><li><strong>Aangevraagd budget: <\/strong>\u20ac 321.950,00.<div id=\"x_x_Signature\">\u00a0<\/div><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-462636e e-con-full e-flex e-con e-child\" data-id=\"462636e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8b3a224 e-flex e-con-boxed e-con e-parent\" data-id=\"8b3a224\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8ebf5f9 e-con-full e-flex e-con e-child\" data-id=\"8ebf5f9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0ae59a1 elementor-widget elementor-widget-heading\" data-id=\"0ae59a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Doelstellingen<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-715299e elementor-widget elementor-widget-text-editor\" data-id=\"715299e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">De ziekte van Parkinson\u00a0is een hersenaandoening die bewegingsproblemen veroorzaakt doordat dopamine-producerende hersencellen afsterven. Een eiwit\u00a0genaamd LRRK2 is vaak overactief bij\u00a0parkinson, wat schadelijk is voor hersencellen. Een ander eiwit, PP2A, werkt als een rem\u00a0die de schadelijke effecten van LRRK2 kan verminderen. Echter, bij\u00a0parkinsonpati\u00ebnten functioneert PP2A minder goed.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Dit onderzoek heeft als doel:<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Beter te begrijpen hoe PP2A en LRRK2 samenwerken in hersen- en immuuncellen.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Manieren te vinden om PP2A te activeren met kleine moleculen genaamd\u00a0SMAPs\u00a0(Small Molecule Activators of PP2A).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Deze mogelijke behandeling te testen in\u00a0celmodellen\u00a0om te kijken of het hersencellen beschermt.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><p><span data-contrast=\"auto\">Als dit succesvol is, kan dit onderzoek een nieuwe strategie bieden om\u00a0parkinson\u00a0te behandelen, door de activiteit van PP2A te herstellen en de schadelijke effecten van LRRK2 te verminderen.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2891daa elementor-widget elementor-widget-heading\" data-id=\"2891daa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Onderzoeksdetails<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1be87d elementor-widget elementor-widget-text-editor\" data-id=\"b1be87d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">Het onderzoek is opgedeeld in drie werkpakketten:<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><p aria-level=\"4\"><span data-contrast=\"auto\">Werkpakket 1: Hoe werken PP2A en LRRK2 in hersen- en immuuncellen?<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;201341983&quot;:0,&quot;335559738&quot;:319,&quot;335559739&quot;:319,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Onderzoeken hoe deze eiwitten samenwerken in hersencellen en immuuncellen.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Bloedmonsters van\u00a0parkinsonpati\u00ebnten en gekweekte muizenneuronen gebruiken.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Kijken hoe deze eiwitten reageren op schadelijke omstandigheden, zoals blootstelling aan ophopingen van alfa-synucle\u00efne\u00a0(een kenmerk van\u00a0parkinson).<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><p aria-level=\"4\"><span data-contrast=\"auto\">Werkpakket 2: Studie van\u00a0pati\u00ebntenmonsters\u00a0en stamcellen<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;201341983&quot;:0,&quot;335559738&quot;:319,&quot;335559739&quot;:319,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Onderzoeken hoeveel PP2A en LRRK2 aanwezig en actief zijn in hersen- en bloedmonsters van\u00a0parkinsonpati\u00ebnten.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Stamcellen (iPSCs) van\u00a0parkinsonpati\u00ebnten gebruiken om hersen- en immuuncellen na te bootsen.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Vergelijken of deze cellen zich anders gedragen bij mensen met\u00a0parkinson\u00a0dan bij gezonde individuen.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><p aria-level=\"4\"><span data-contrast=\"auto\">Werkpakket 3: Testen van PP2A-activerende medicijnen (SMAPs)<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;201341983&quot;:0,&quot;335559738&quot;:319,&quot;335559739&quot;:319,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">PP2A-activerende medicijnen (SMAPs) testen in hersen- en immuuncelmodellen.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Bekijken of deze medicijnen neuronen kunnen beschermen tegen schade door LRRK2 en alfa-synucle\u00efne.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Samenwerken met RAPPTA\u00a0Therapeutics, een bedrijf dat PP2A-gerichte medicijnen ontwikkelt.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d992fe8 elementor-widget elementor-widget-heading\" data-id=\"d992fe8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Gewenste resultaten<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d1449e elementor-widget elementor-widget-text-editor\" data-id=\"9d1449e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW246043025 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW246043025 BCX0\">Bevestigen dat PP2A een sleutelrol speelt in de regulatie van LRRK2 bij\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">arkinson<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">\u00a0en n<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">ieuwe manieren ontdekken om PP2A-activiteit te herstellen in\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">arkinsonmodellen<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">.<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">\u00a0Ook willen de onderzoekers t<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">esten of bepaalde medicijnen (<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">SMAPs<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">) effectief zijn als\u00a0<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">mogelijke\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">arkinson<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">-behandeling.<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">\u00a0<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">Als deze medicijnen werken, kunnen ze mogelijk het ziekteproces vertragen en een nieuwe behandelingsoptie bieden voor\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">arkinso<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW246043025 BCX0\">n<\/span><span class=\"NormalTextRun SCXW246043025 BCX0\">.<\/span><\/span><span class=\"EOP SCXW246043025 BCX0\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e7b42 elementor-widget elementor-widget-heading\" data-id=\"56e7b42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Betekenis voor pati\u00ebnten, onderzoekers en financiers<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-181083a elementor-widget elementor-widget-text-editor\" data-id=\"181083a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">Voor pati\u00ebnten\u00a0en\u00a0mantelzorgers\u00a0kan dit\u00a0onderzoek leiden tot een nieuwe behandeling die anders werkt dan de huidige dopamine-therapie\u00ebn.\u00a0In plaats van alleen symptomen te bestrijden, richt deze aanpak zich op het beschermen van hersencellen.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Voor wetenschappers\u00a0en\u00a0artsen\u00a0geeft de studie\u00a0nieuwe inzichten in hoe\u00a0parkinson\u00a0ontstaat en hoe hersencellen worden aangetast.\u00a0Dit\u00a0leidt\u00a0naar therapie\u00ebn die zich richten op PP2A-regulatie.<\/span>\u00a0<br \/><span data-contrast=\"auto\">Voor investeerders\u00a0en\u00a0farmaceutische bedrijven\u00a0kan dit\u00a0onderzoek de basis leggen voor klinische tests van PP2A-gerichte medicijnen.\u00a0De samenwerking met RAPPTA\u00a0Therapeutics\u00a0toont aan dat de industrie interesse heeft in deze behandelingsaanpak.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Dit onderzoek heeft het potentieel om de behandeling van\u00a0parkinson\u00a0te veranderen door niet alleen de symptomen te verlichten, maar ook het ziekteproces zelf te vertragen.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:240,&quot;335559739&quot;:240,&quot;335559740&quot;:279}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8da9c58 elementor-widget elementor-widget-heading\" data-id=\"8da9c58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Hoe kun je helpen?\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ef34d3 elementor-widget elementor-widget-text-editor\" data-id=\"0ef34d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Zonder de ruimhartige steun van mensen zoals jij, kunnen wij geen baanbrekend onderzoek steunen. Help je ook mee met een donatie voor onderzoek?<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-497ef39 elementor-widget elementor-widget-button\" data-id=\"497ef39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/doneren\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Doneer voor onderzoek<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bd0ce5f e-con-full e-flex e-con e-child\" data-id=\"bd0ce5f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f0d1cf8 e-flex e-con-boxed e-con e-parent\" data-id=\"f0d1cf8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-74539a6 e-flex e-con-boxed e-con e-child\" data-id=\"74539a6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7029e1e elementor-widget elementor-widget-heading\" data-id=\"7029e1e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Deel dit artikel<\/h5>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-316c926 e-flex e-con-boxed e-con e-child\" data-id=\"316c926\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-892ad79 elementor-share-buttons--view-icon elementor-share-buttons--skin-flat elementor-share-buttons--color-custom elementor-widget__width-auto elementor-share-buttons--shape-square elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"892ad79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_twitter\" role=\"button\" tabindex=\"0\" aria-label=\"Share on twitter\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-twitter\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M459.37 151.716c.325 4.548.325 9.097.325 13.645 0 138.72-105.583 298.558-298.558 298.558-59.452 0-114.68-17.219-161.137-47.106 8.447.974 16.568 1.299 25.34 1.299 49.055 0 94.213-16.568 130.274-44.832-46.132-.975-84.792-31.188-98.112-72.772 6.498.974 12.995 1.624 19.818 1.624 9.421 0 18.843-1.3 27.614-3.573-48.081-9.747-84.143-51.98-84.143-102.985v-1.299c13.969 7.797 30.214 12.67 47.431 13.319-28.264-18.843-46.781-51.005-46.781-87.391 0-19.492 5.197-37.36 14.294-52.954 51.655 63.675 129.3 105.258 216.365 109.807-1.624-7.797-2.599-15.918-2.599-24.04 0-57.828 46.782-104.934 104.934-104.934 30.213 0 57.502 12.67 76.67 33.137 23.715-4.548 46.456-13.32 66.599-25.34-7.798 24.366-24.366 44.833-46.132 57.827 21.117-2.273 41.584-8.122 60.426-16.243-14.292 20.791-32.161 39.308-52.628 54.253z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_facebook\" role=\"button\" tabindex=\"0\" aria-label=\"Share on 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512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M380.9 97.1C339 55.1 283.2 32 223.9 32c-122.4 0-222 99.6-222 222 0 39.1 10.2 77.3 29.6 111L0 480l117.7-30.9c32.4 17.7 68.9 27 106.1 27h.1c122.3 0 224.1-99.6 224.1-222 0-59.3-25.2-115-67.1-157zm-157 341.6c-33.2 0-65.7-8.9-94-25.7l-6.7-4-69.8 18.3L72 359.2l-4.4-7c-18.5-29.4-28.2-63.3-28.2-98.2 0-101.7 82.8-184.5 184.6-184.5 49.3 0 95.6 19.2 130.4 54.1 34.8 34.9 56.2 81.2 56.1 130.5 0 101.8-84.9 184.6-186.6 184.6zm101.2-138.2c-5.5-2.8-32.8-16.2-37.9-18-5.1-1.9-8.8-2.8-12.5 2.8-3.7 5.6-14.3 18-17.6 21.8-3.2 3.7-6.5 4.2-12 1.4-32.6-16.3-54-29.1-75.5-66-5.7-9.8 5.7-9.1 16.3-30.3 1.8-3.7.9-6.9-.5-9.7-1.4-2.8-12.5-30.1-17.1-41.2-4.5-10.8-9.1-9.3-12.5-9.5-3.2-.2-6.9-.2-10.6-.2-3.7 0-9.7 1.4-14.8 6.9-5.1 5.6-19.4 19-19.4 46.3 0 27.3 19.9 53.7 22.6 57.4 2.8 3.7 39.1 59.7 94.8 83.8 35.2 15.2 49 16.5 66.6 13.9 10.7-1.6 32.8-13.4 37.4-26.4 4.6-13 4.6-24.1 3.2-26.4-1.3-2.5-5-3.9-10.5-6.6z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f203929 elementor-widget__width-auto custom-share elementor-widget elementor-widget-html\" data-id=\"f203929\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<a class=\"shadow-one\" onclick=\"shareTheLink()\">\n    <span> Anders<\/span>\n<\/a>    \n<script src=\"https:\/\/unpkg.com\/share-api-polyfill\/dist\/share-min.js\"><\/script>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>De ziekte van Parkinson is een hersenaandoening die bewegingsproblemen veroorzaakt doordat dopamine-producerende hersencellen afsterven. Een eiwit genaamd LRRK2 is vaak overactief bij parkinson, wat schadelijk is voor hersencellen. Een ander eiwit, PP2A, werkt als een rem die de schadelijke effecten van LRRK2 kan verminderen. Echter, bij parkinsonpati\u00ebnten functioneert PP2A minder goed. Daarom willen we met ons onderzoek beter begrijpen hoe PP2A en LRRK2 samenwerken in hersen- en immuuncellen. Ook willen we manieren vinden om het PP2A complex te stabiliseren en te activeren met kleine moleculen genaamd SMAPs (Small Molecule Activators of PP2A). Deze mogelijke behandeling gaan we testen in celmodellen om te kijken of het hersencellen beschermt. Als dit succesvol is, kan dit onderzoek een nieuwe strategie bieden om parkinson te behandelen, door de activiteit van PP2A te herstellen en de schadelijke effecten van LRRK2 te verminderen.<\/p>\n","protected":false},"featured_media":38256,"parent":0,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"soort-onderzoek":[42],"class_list":["post-38221","onderzoek","type-onderzoek","status-publish","has-post-thumbnail","hentry","soort-onderzoek-genen"],"acf":[],"_links":{"self":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/38221","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek"}],"about":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/types\/onderzoek"}],"version-history":[{"count":13,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/38221\/revisions"}],"predecessor-version":[{"id":38266,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/38221\/revisions\/38266"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media\/38256"}],"wp:attachment":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media?parent=38221"}],"wp:term":[{"taxonomy":"soort-onderzoek","embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/soort-onderzoek?post=38221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}