{"id":38560,"date":"2026-08-05T16:17:44","date_gmt":"2026-08-05T14:17:44","guid":{"rendered":"https:\/\/parkinsonfonds.nl\/?post_type=onderzoek&#038;p=38560"},"modified":"2026-08-05T16:20:26","modified_gmt":"2026-08-05T14:20:26","slug":"hoe-hersencellen-uitvallen-bij-lewy-body-ziekte","status":"publish","type":"onderzoek","link":"https:\/\/parkinsonfonds.nl\/en\/onderzoek\/hoe-hersencellen-uitvallen-bij-lewy-body-ziekte\/","title":{"rendered":"Hoe hersencellen uitvallen bij Lewy body ziekte"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"38560\" class=\"elementor elementor-38560\" data-elementor-post-type=\"onderzoek\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb5ee3b overview-light hero-header e-flex e-con-boxed e-con e-child\" data-id=\"cb5ee3b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-25fc975 hero-section_holder e-flex e-con-boxed e-con e-child\" data-id=\"25fc975\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3a0a5fa e-flex e-con-boxed e-con e-child\" data-id=\"3a0a5fa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b727955 elementor-widget elementor-widget-button\" data-id=\"b727955\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/onderzoek\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-left\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M34.52 239.03L228.87 44.69c9.37-9.37 24.57-9.37 33.94 0l22.67 22.67c9.36 9.36 9.37 24.52.04 33.9L131.49 256l154.02 154.75c9.34 9.38 9.32 24.54-.04 33.9l-22.67 22.67c-9.37 9.37-24.57 9.37-33.94 0L34.52 272.97c-9.37-9.37-9.37-24.57 0-33.94z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Terug naar overzicht<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a290605 e-flex e-con-boxed e-con e-child\" data-id=\"a290605\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f4af2d elementor-widget elementor-widget-heading\" data-id=\"7f4af2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-small\">Hoe hersencellen uitvallen bij Lewy body ziekte<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5344dd1 elementor-widget elementor-widget-post-info\" data-id=\"5344dd1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-f7ba8bf elementor-inline-item\" itemprop=\"about\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-terms\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-post-info__terms-list\">\n\t\t\t\t<span class=\"elementor-post-info__terms-list-item\">Veroudering<\/span>\t\t\t\t<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-6e7f5d8 elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>5 August 2026<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fbb410c e-flex e-con-boxed e-con e-parent\" data-id=\"fbb410c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-bb15954 e-con-full e-flex e-con e-child\" data-id=\"bb15954\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-648bebd elementor-widget elementor-widget-text-editor\" data-id=\"648bebd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\"><p><b><span data-contrast=\"auto\">Offici\u00eble\u00a0titel:<\/span><\/b><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">Brainstem\u00a0neuromodulatory\u00a0hub degeneration in Lewy body disease:\u00a0identifying\u00a0diffusion MRI biomarkers of cholinergic,\u00a0noradrenergic\u00a0and dopaminergic failure<\/span><\/p><\/li><li class=\"p1\"><p><b><span data-contrast=\"auto\">Onderzoeker:<\/span><\/b><span data-contrast=\"auto\">\u00a0dr.\u00a0<\/span><span data-contrast=\"auto\">Laura\u00a0Jonkman, in samenwerking met\u00a0dr.\u00a0Mario Tranfa<\/span>\u00a0<br \/><b><\/b><\/p><\/li><li class=\"p1\"><p><b><span data-contrast=\"auto\">Instituut:<\/span><\/b><span data-contrast=\"auto\">\u00a0afdeling\u00a0Anatomie en Neurowetenschappen, Amsterdam UMC<\/span><\/p><\/li><li class=\"p1\"><p><b><span data-contrast=\"auto\">Duur van het onderzoek:<\/span><\/b><span data-contrast=\"auto\">\u00a031 maanden\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><\/li><li class=\"p1\"><p><b><span data-contrast=\"auto\">Bedrag:<\/span><\/b><span data-contrast=\"auto\"> \u20ac284.839,-<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-462636e e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"462636e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8b3a224 e-flex e-con-boxed e-con e-parent\" data-id=\"8b3a224\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8ebf5f9 e-con-full e-flex e-con e-child\" data-id=\"8ebf5f9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0ae59a1 elementor-widget elementor-widget-heading\" data-id=\"0ae59a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Onderzoeksdomein<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-715299e elementor-widget elementor-widget-text-editor\" data-id=\"715299e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p aria-level=\"1\"><span data-contrast=\"auto\">Dit onderzoek richt zich op veroudering, beeldvorming en cellulaire processen.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"0\" data-aria-level=\"1\"><span data-contrast=\"auto\">Veroudering:\u00a0Lewy\u00a0body-ziekten zijn neurodegeneratieve aandoeningen waarbij zenuwcellen geleidelijk verloren gaan en het eiwit alfa-synucle\u00efne\u00a0zich ophoopt in de hersenen.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Beeldvorming: Met geavanceerde MRI-technieken brengen de onderzoekers veranderingen in hersenverbindingen en -netwerken in kaart.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"8\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Cellulaire processen: Het onderzoek kijkt hoe schade aan specifieke zenuwcellen en hersengebieden leidt tot veranderingen in de verbindingen tussen hersengebieden.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5e45dc elementor-widget elementor-widget-heading\" data-id=\"d5e45dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Doelstellingen<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-03e2cdd elementor-widget elementor-widget-text-editor\" data-id=\"03e2cdd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p aria-level=\"1\"><span data-contrast=\"auto\">De ziekte van Parkinson,\u00a0parkinsondementie en dementie met\u00a0Lewy\u00a0bodies\u00a0behoren tot de groep\u00a0Lewy\u00a0body-ziekten. Deze aandoeningen hebben een belangrijk biologisch kenmerk gemeen: de ophoping van het eiwit alfa-synucle\u00efne, waardoor zenuwcellen beschadigd raken en uiteindelijk afsterven.\u00a0<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Bij\u00a0parkinson is vooral het verlies van dopamine-producerende zenuwcellen in de substantia nigra bekend. Dit veroorzaakt veel van de typische bewegingsklachten, zoals trillen, stijfheid en traagheid. Steeds duidelijker wordt echter dat de ziekte m\u00e9\u00e9r is dan alleen een tekort aan dopamine. Ook andere neurotransmittersystemen raken aangetast.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Dit onderzoek richt zich op drie belangrijke hersenstamgebieden die verschillende chemische signalen aansturen:<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Substantia nigra\u00a0&gt;\u00a0dopamine systeem<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Locus\u00a0coeruleus\u00a0\u00a0&gt;\u00a0noradrenaline systeem<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/li><li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"6\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">Pedunculopontine\u00a0nucleus\u00a0&gt;\u00a0acetylcholine systeem<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a08f8b3 elementor-widget elementor-widget-text-editor\" data-id=\"a08f8b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">Deze gebieden functioneren als centrale &#8216;knooppunten&#8217; die de communicatie tussen verschillende hersengebieden ondersteunen. Wanneer deze knooppunten beschadigd raken, kunnen complete hersennetwerken ontregeld raken. Dat kan verklaren waarom veel mensen met parkinson naast bewegingsproblemen ook cognitieve achteruitgang ontwikkelen. Juist deze klachten reageren vaak minder goed op de huidige dopaminerge behandelingen.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Het doel van dit onderzoek is te begrijpen hoe schade aan deze hersenstamgebieden leidt tot verstoringen in hersennetwerken en uiteindelijk tot de verschillende symptomen van\u00a0Lewy\u00a0body-ziekten.<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2891daa elementor-widget elementor-widget-heading\" data-id=\"2891daa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Onderzoeksdetails<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1be87d elementor-widget elementor-widget-text-editor\" data-id=\"b1be87d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p aria-level=\"1\"><span data-contrast=\"auto\">De onderzoekers\u00a0gaan\u00a0hersenen van 60 donoren bestuderen:\u00a030 donoren met\u00a0een\u00a0Lewy\u00a0body ziekte\u00a0en\u00a030 controle-donoren zonder\u00a0een\u00a0neurologische\u00a0aandoening.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Van alle donoren zijn kort na overlijden MRI-scans gemaakt. Die scans worden gecombineerd met gedetailleerd microscopisch onderzoek van hetzelfde hersenweefsel. Deze unieke combinatie maakt het mogelijk om veranderingen die zichtbaar zijn op MRI direct te vergelijken met de daadwerkelijke biologische veranderingen in de hersenen.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Met diffusie-MRI brengen de onderzoekers de verbindingsbanen tussen hersengebieden in kaart. Vervolgens onderzoeken zij onder de microscoop hoeveel zenuwcellen nog aanwezig zijn, hoeveel alfa-synucle\u00efne\u00a0zich heeft opgehoopt en welke andere ziekte- of verouderingsprocessen zichtbaar zijn.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Door deze gegevens te combineren kunnen zij vaststellen of veranderingen op MRI daadwerkelijk overeenkomen met de onderliggende hersenschade.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Daarnaast gebruiken de onderzoekers geavanceerde netwerkanalyses (graph\u00a0theory) om te onderzoeken hoe goed verschillende hersengebieden binnen \u00e9n tussen hersennetwerken met elkaar samenwerken.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d992fe8 elementor-widget elementor-widget-heading\" data-id=\"d992fe8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Gewenst resultaat<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d1449e elementor-widget elementor-widget-text-editor\" data-id=\"9d1449e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p aria-level=\"1\"><span data-contrast=\"auto\">De onderzoekers verwachten dat schade aan de verschillende neurotransmittersystemen ieder een eigen effect heeft op de hersennetwerken.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p aria-level=\"1\"><span data-contrast=\"auto\">Verlies van cholinerge zenuwcellen kan de samenwerking verstoren tussen hersengebieden die dezelfde functie uitvoeren. Dit hangt waarschijnlijk samen met cognitieve problemen.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p aria-level=\"1\"><span data-contrast=\"auto\">Verlies van\u00a0noradrenerge\u00a0en dopaminerge zenuwcellen kan de samenwerking verstoren tussen hersengebieden die een andere functie uitvoeren. Dit kan bijdragen aan problemen met aandacht, denken en bewegen.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p aria-level=\"1\"><span data-contrast=\"auto\">Het uiteindelijke doel is MRI-biomarkers\u00a0te ontwikkelen die betrouwbaar kunnen aangeven hoe gezond deze neurotransmittersystemen nog zijn bij (nog levende) mensen met\u00a0Lewy\u00a0body-ziekten.<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:0,&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56e7b42 elementor-widget elementor-widget-heading\" data-id=\"56e7b42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Context voor pati\u00ebnten, onderzoekers, mantelzorgers en financiers<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-181083a elementor-widget elementor-widget-text-editor\" data-id=\"181083a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\">Veel klachten van mensen met\u00a0parkinson, zoals cognitieve achteruitgang, loopproblemen en balansstoornissen, reageren onvoldoende op de huidige dopaminerge medicatie. Een belangrijke verklaring kan zijn dat naast het dopaminesysteem ook andere\u00a0neurotransmittersystemen beschadigd raken, zoals het acetylcholine- en noradrenalinesysteem. Op dit moment zijn er nauwelijks mogelijkheden om die schade bij levende pati\u00ebnten goed in beeld te brengen.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Als MRI betrouwbare\u00a0biomarkers\u00a0kan opleveren, biedt dat artsen de mogelijkheid om beter vast te stellen welke hersensystemen zijn aangedaan, het ziekteverloop nauwkeuriger te voorspellen en behandelingen beter af te stemmen op de individuele pati\u00ebnt.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Bijvoorbeeld: zo zouden pati\u00ebnten met veel cholinerge schade mogelijk meer baat hebben bij\u00a0cholinesteraseremmers, terwijl voor andere pati\u00ebnten juist een behandeling gericht op een ander neurotransmittersysteem geschikter is.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Voor onderzoekers vormt dit onderzoek bovendien een belangrijke stap in het verbinden van veranderingen op celniveau met verstoringen van hersennetwerken en de symptomen die pati\u00ebnten ervaren. Die kennis kan bijdragen aan de ontwikkeling van meer gepersonaliseerde behandelingen voor\u00a0parkinson en andere\u00a0Lewy\u00a0body-ziekten.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:240}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8da9c58 elementor-widget elementor-widget-heading\" data-id=\"8da9c58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Hoe kun je helpen?\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ef34d3 elementor-widget elementor-widget-text-editor\" data-id=\"0ef34d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Zonder de ruimhartige steun van mensen zoals jij, kunnen wij geen baanbrekend onderzoek steunen. Help je ook mee met een donatie voor onderzoek?<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-497ef39 elementor-widget elementor-widget-button\" data-id=\"497ef39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/doneren\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Doneer voor onderzoek<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bd0ce5f e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"bd0ce5f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f0d1cf8 e-flex e-con-boxed e-con e-parent\" data-id=\"f0d1cf8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-74539a6 e-flex e-con-boxed e-con e-child\" data-id=\"74539a6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7029e1e elementor-widget elementor-widget-heading\" data-id=\"7029e1e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Deel dit artikel<\/h5>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-316c926 e-flex e-con-boxed e-con e-child\" data-id=\"316c926\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div 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viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M380.9 97.1C339 55.1 283.2 32 223.9 32c-122.4 0-222 99.6-222 222 0 39.1 10.2 77.3 29.6 111L0 480l117.7-30.9c32.4 17.7 68.9 27 106.1 27h.1c122.3 0 224.1-99.6 224.1-222 0-59.3-25.2-115-67.1-157zm-157 341.6c-33.2 0-65.7-8.9-94-25.7l-6.7-4-69.8 18.3L72 359.2l-4.4-7c-18.5-29.4-28.2-63.3-28.2-98.2 0-101.7 82.8-184.5 184.6-184.5 49.3 0 95.6 19.2 130.4 54.1 34.8 34.9 56.2 81.2 56.1 130.5 0 101.8-84.9 184.6-186.6 184.6zm101.2-138.2c-5.5-2.8-32.8-16.2-37.9-18-5.1-1.9-8.8-2.8-12.5 2.8-3.7 5.6-14.3 18-17.6 21.8-3.2 3.7-6.5 4.2-12 1.4-32.6-16.3-54-29.1-75.5-66-5.7-9.8 5.7-9.1 16.3-30.3 1.8-3.7.9-6.9-.5-9.7-1.4-2.8-12.5-30.1-17.1-41.2-4.5-10.8-9.1-9.3-12.5-9.5-3.2-.2-6.9-.2-10.6-.2-3.7 0-9.7 1.4-14.8 6.9-5.1 5.6-19.4 19-19.4 46.3 0 27.3 19.9 53.7 22.6 57.4 2.8 3.7 39.1 59.7 94.8 83.8 35.2 15.2 49 16.5 66.6 13.9 10.7-1.6 32.8-13.4 37.4-26.4 4.6-13 4.6-24.1 3.2-26.4-1.3-2.5-5-3.9-10.5-6.6z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f203929 elementor-widget__width-auto custom-share elementor-widget elementor-widget-html\" data-id=\"f203929\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<a class=\"shadow-one\" onclick=\"shareTheLink()\">\n    <span> Anders<\/span>\n<\/a>    \n<script src=\"https:\/\/unpkg.com\/share-api-polyfill\/dist\/share-min.js\"><\/script>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>De ziekte van Parkinson, parkinsondementie en dementie met Lewy bodies behoren tot de groep Lewy body-ziekten. Deze aandoeningen hebben een belangrijk biologisch kenmerk gemeen: de ophoping van het eiwit alfa-synucle\u00efne, waardoor zenuwcellen beschadigd raken en uiteindelijk afsterven.  <\/p>\n","protected":false},"featured_media":38561,"parent":0,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"soort-onderzoek":[43],"class_list":["post-38560","onderzoek","type-onderzoek","status-publish","has-post-thumbnail","hentry","soort-onderzoek-veroudering"],"acf":[],"_links":{"self":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/38560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek"}],"about":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/types\/onderzoek"}],"version-history":[{"count":4,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/38560\/revisions"}],"predecessor-version":[{"id":38566,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/38560\/revisions\/38566"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media\/38561"}],"wp:attachment":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media?parent=38560"}],"wp:term":[{"taxonomy":"soort-onderzoek","embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/soort-onderzoek?post=38560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}