{"id":9158,"date":"2023-12-14T13:30:31","date_gmt":"2023-12-14T12:30:31","guid":{"rendered":"https:\/\/parkinsonfonds.mysites.io\/?post_type=onderzoek&#038;p=9158"},"modified":"2025-04-01T16:42:25","modified_gmt":"2025-04-01T14:42:25","slug":"welke-moleculaire-mechanismen-veroorzaken-erfelijke-vormen-van-parkinson","status":"publish","type":"onderzoek","link":"https:\/\/parkinsonfonds.nl\/en\/onderzoek\/welke-moleculaire-mechanismen-veroorzaken-erfelijke-vormen-van-parkinson\/","title":{"rendered":"Welke moleculaire mechanismen veroorzaken erfelijke vormen van parkinson?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"9158\" class=\"elementor elementor-9158\" data-elementor-post-type=\"onderzoek\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb5ee3b overview-light hero-header e-flex e-con-boxed e-con e-child\" data-id=\"cb5ee3b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-25fc975 hero-section_holder e-flex e-con-boxed e-con e-child\" data-id=\"25fc975\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3a0a5fa e-flex e-con-boxed e-con e-child\" data-id=\"3a0a5fa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b727955 elementor-widget elementor-widget-button\" data-id=\"b727955\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/onderzoek\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-chevron-left\" viewBox=\"0 0 320 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M34.52 239.03L228.87 44.69c9.37-9.37 24.57-9.37 33.94 0l22.67 22.67c9.36 9.36 9.37 24.52.04 33.9L131.49 256l154.02 154.75c9.34 9.38 9.32 24.54-.04 33.9l-22.67 22.67c-9.37 9.37-24.57 9.37-33.94 0L34.52 272.97c-9.37-9.37-9.37-24.57 0-33.94z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Terug naar overzicht<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a290605 e-flex e-con-boxed e-con e-child\" data-id=\"a290605\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f4af2d elementor-widget elementor-widget-heading\" data-id=\"7f4af2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-small\">Welke moleculaire mechanismen veroorzaken erfelijke vormen van parkinson?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5344dd1 elementor-widget elementor-widget-post-info\" data-id=\"5344dd1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-f7ba8bf elementor-inline-item\" itemprop=\"about\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-terms\">\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-post-info__terms-list\">\n\t\t\t\t<span class=\"elementor-post-info__terms-list-item\">Genen<\/span>\t\t\t\t<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-b920ad1 elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>December 14, 2023<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5429ea3 e-flex e-con-boxed e-con e-parent\" data-id=\"5429ea3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3c9278e e-con-full e-flex e-con e-child\" data-id=\"3c9278e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d10d097 elementor-widget elementor-widget-text-editor\" data-id=\"d10d097\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"none\"><strong>Studie:<\/strong> Welke moleculaire mechanismen veroorzaken erfelijke vormen van parkinson?<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559738&quot;:0,&quot;335559740&quot;:240,&quot;469777462&quot;:[560,1120,1680,2240,2800,3360,3920,4480,5040,5600,6160,6720,7280,7840,8400,8566,8566],&quot;469777927&quot;:[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],&quot;469777928&quot;:[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1]}\">\u00a0<\/span><\/p><p><span data-contrast=\"none\"><strong>Onderzoeker:<\/strong> dr. Wim Mandemakers (Erasmus MC)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><p><span data-contrast=\"none\"><strong>Looptijd:<\/strong> 4 jaar<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><p><span data-contrast=\"none\"><strong>Subsidie:<\/strong> \u20ac 326.000,00<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-79ff532 e-con-full e-flex e-con e-child\" data-id=\"79ff532\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c29a50d elementor-widget elementor-widget-image\" data-id=\"c29a50d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2023\/12\/Mandemakers-300x300.png\" class=\"attachment-medium size-medium wp-image-9130\" alt=\"Wim Mandemakers\" srcset=\"https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2023\/12\/Mandemakers-300x300.png.webp 300w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2023\/12\/Mandemakers-1024x1024.png.webp 1024w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2023\/12\/Mandemakers-150x150.png.webp 150w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2023\/12\/Mandemakers-768x768.png.webp 768w, https:\/\/parkinsonfonds.nl\/wp-content\/uploads\/2023\/12\/Mandemakers.png.webp 1080w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Dr. Wim Mandemakers<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d0bc9c1 e-flex e-con-boxed e-con e-parent\" data-id=\"d0bc9c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c1d8641 e-con-full e-flex e-con e-child\" data-id=\"c1d8641\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-711820c elementor-widget elementor-widget-heading\" data-id=\"711820c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Wat is het doel van het onderzoek? <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93dc3e4 elementor-widget elementor-widget-text-editor\" data-id=\"93dc3e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW252369217 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW252369217 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">Het belangrijkste doel van ons onderzoek is het in kaart brengen van de moleculaire mechanismen die erfelijke vormen van de ziekte van Parkinson veroorzaken. Wat zijn de gevolgen van deze <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW252369217 BCX0\">genmutaties<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> en waarom leiden juist deze mutaties tot het afsterven van de dopamine neuronen in de hersenen? Wat is het mechanisme? Dat proberen wij te ontrafelen. In onze nieuwste studie <\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">gebruiken we<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> geavanceerde celkweeksystemen. We kunnen nu bijvoorbeeld met huid of bloedcellen<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">,<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> die vrijwillig zijn afgestaan door donoren met de ziekte van Parkinson<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">,<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> met speciale technieken<\/span> <span class=\"NormalTextRun SCXW252369217 BCX0\">kleine bolletjes hersenen laten groeien<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">, <\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">ook wel <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW252369217 BCX0\">organo\u00efden<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> genoemd<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">. Q<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">ua structuur en opbouw <\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">komen deze <\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">erg over<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">een<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> met de echte hersenen. De kracht van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW252369217 BCX0\">organo\u00efden<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> is dat je de ontwikkeling van dopamine neuronen kunt volgen in een omgeving net zoals in de hersenen van de donoren zelf<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">. Zo kun je<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> dus ook mogelijk het ontstaan van de ziekte volgen. Dat levert meer informatie op, bijvoorbeeld over de rol <\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">van <\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">een <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW252369217 BCX0\">genmutatie<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\"> in het ontstaan van de ziekte van Parkinson nog voordat de dopamine neuronen afsterven.<\/span><span class=\"NormalTextRun SCXW252369217 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW252369217 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b164eaa e-con-full e-flex e-con e-child\" data-id=\"b164eaa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aa5e1bf e-flex e-con-boxed e-con e-parent\" data-id=\"aa5e1bf\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-37e3822 e-con-full e-flex e-con e-child\" data-id=\"37e3822\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-186e910 elementor-widget elementor-widget-heading\" data-id=\"186e910\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Waarom is het onderzoek waardevol? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3e5b53 elementor-widget elementor-widget-text-editor\" data-id=\"b3e5b53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"none\">\u201cHet is uniek dat we dankzij de hulp van de donoren met parkinson een modelsysteem van menselijk materiaal kunnen maken. Hoewel genetische afwijkingen maar in een klein aantal individuen met de parkinson voorkomen, geeft ons onderzoek belangrijke aanwijzingen om heel specifiek te kijken naar afwijkingen in cellen die mogelijk ook een belangrijke rol spelen in andere, meer algemene niet erfelijke vormen van de ziekte van Parkinson.\u201d<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bfb4c62 elementor-widget elementor-widget-heading\" data-id=\"bfb4c62\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Waarom is fundamenteel onderzoek zo belangrijk? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ce6ee0 elementor-widget elementor-widget-text-editor\" data-id=\"0ce6ee0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW35505424 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW35505424 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW35505424 BCX0\">Fundamenteel wetenschappelijk onderzoek is ontzettend belangrijk omdat we hiermee onder andere de genetische oorzaken van de ziekte van Parkinson in kaart kunnen brengen<\/span><span class=\"NormalTextRun SCXW35505424 BCX0\">. Dat biedt<\/span><span class=\"NormalTextRun SCXW35505424 BCX0\"> mogelijkhede<\/span><span class=\"NormalTextRun SCXW35505424 BCX0\">n <\/span><span class=\"NormalTextRun SCXW35505424 BCX0\">voor <\/span><span class=\"NormalTextRun SCXW35505424 BCX0\">de <\/span><span class=\"NormalTextRun SCXW35505424 BCX0\">ontwikkeling van een gerichte therapie om een genezing te vinden voor <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW35505424 BCX0\">parkinson<\/span><span class=\"NormalTextRun SCXW35505424 BCX0\">, om de ziekte af te remmen of te voorkomen.<\/span><span class=\"NormalTextRun SCXW35505424 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW35505424 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8287a06 elementor-widget elementor-widget-heading\" data-id=\"8287a06\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Welke ontwikkelingen verwacht je rond parkinsononderzoek? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1605eb3 elementor-widget elementor-widget-text-editor\" data-id=\"1605eb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW183170581 BCX0\" lang=\"NL-NL\" xml:lang=\"NL-NL\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW183170581 BCX0\">\u201c<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">Dankzij de constante innovatie in fundamenteel onderzoek is het sinds <\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">kort<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\"> ook mogelijk om <\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">de <\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">expressie van alle genen per individuele hersencel op elk moment van het ziekteproces te bepalen. Hierdoor <\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">worden<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\"> de ziekteprocessen met nog meer detail in kaart gebracht<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">,<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\"> wat nog meer mogelijkheden zal bieden voor therapieontwikkeling. Daarnaast zijn er ook veelbelovende ontdekkingen gedaan op het gebied van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW183170581 BCX0\">biomarkers<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">. Dat biedt <\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">mogelijkheden om de ziekte van Parkinson <\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">in<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\"> een steeds vroeger stadium vast te stellen<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">,<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\"> waardoor de ziekte eerder kan worden behandeld. Er zijn de afgelopen jaren ook medicijnen ontwikkeld die in de nabije toekomst getest worden in <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW183170581 BCX0\">clinical<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\"> trials die gebaseerd zijn op fundamenteel onderzoek naar genetische vormen van de ziekte van Parkinson. Tevens zal het fundamentele onderzoek aanknopingspunten geven voor mogelijke preventieve maatregelen om het ontstaan van de ziekte van Parkinson te voorkomen. Bij al deze ontwikkelingen zal het gebruik van <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW183170581 BCX0\">artificial<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\"> intelligence (AI) een grote rol gaan spelen. Deze nieuwe ontwikkelingen tonen aan dat fundamenteel onderzoek de belangrijkste manier <\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">is <\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">om een genezing te vinden voor <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW183170581 BCX0\">p<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW183170581 BCX0\">arkinson<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">, of om de ziekte uiteindelijk te voorkomen dankzij financi\u00eble steun van donateurs.<\/span><span class=\"NormalTextRun SCXW183170581 BCX0\">\u201d<\/span><\/span><span class=\"EOP SCXW183170581 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8144ca2 e-con-full e-flex e-con e-child\" data-id=\"8144ca2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div 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13.9 10.7-1.6 32.8-13.4 37.4-26.4 4.6-13 4.6-24.1 3.2-26.4-1.3-2.5-5-3.9-10.5-6.6z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f203929 elementor-widget__width-auto custom-share elementor-widget elementor-widget-html\" data-id=\"f203929\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<a class=\"shadow-one\" onclick=\"shareTheLink()\">\n    <span> Anders<\/span>\n<\/a>    \n<script src=\"https:\/\/unpkg.com\/share-api-polyfill\/dist\/share-min.js\"><\/script>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Het belangrijkste doel van ons onderzoek is het in kaart brengen van de moleculaire mechanismen die erfelijke vormen van de ziekte van Parkinson veroorzaken. Wat zijn de gevolgen van deze genmutaties en waarom leiden juist deze mutaties tot het afsterven van de dopamine neuronen in de hersenen? Wat is het mechanisme? Dat proberen wij te ontrafelen.<\/p>\n","protected":false},"featured_media":8624,"parent":0,"template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"soort-onderzoek":[42],"class_list":["post-9158","onderzoek","type-onderzoek","status-publish","has-post-thumbnail","hentry","soort-onderzoek-genen"],"acf":[],"_links":{"self":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/9158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek"}],"about":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/types\/onderzoek"}],"version-history":[{"count":10,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/9158\/revisions"}],"predecessor-version":[{"id":30329,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/onderzoek\/9158\/revisions\/30329"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media\/8624"}],"wp:attachment":[{"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/media?parent=9158"}],"wp:term":[{"taxonomy":"soort-onderzoek","embeddable":true,"href":"https:\/\/parkinsonfonds.nl\/en\/wp-json\/wp\/v2\/soort-onderzoek?post=9158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}